According to the press service, Belgorod State University geneticists played a key role in the development of a universal vaccine to protect animals from these two common infections. For the first time in Russia, a unique strain of Salmonella enteritidis R-6 ecp-schomo was developed, providing simultaneous protection against two pathogens that pose a serious threat to the poultry and livestock industries.
Currently, animals are vaccinated against salmonellosis and colibacillosis using separate preparations. This new development will allow vaccination against both infections using a single vaccine. This will lead to increased effectiveness of preventive measures and cost savings.
As explained by the press service, the new strain was created based on a modified Salmonella enteritidis bacterium. A plasmid fragment containing the DNA region of the ecpABCD bacterium, strain 388 of Escherichia coli, was inserted into its genome. The modified cells actively synthesize proteins from this DNA region, developing robust immunity to salmonellosis and colibacillosis in the animals.
Alexey Deikin, Director of the Joint Center for Genetic Technologies at Belgorod State University, noted that the center acted as the project's scientific leader and technological integrator, successfully transforming industry demand into a scientific solution and assembling a team for its implementation.
The vaccine has successfully completed the necessary trials and is in the registration process with the Russian Ministry of Agriculture. Patent priority has been granted, and the Salmonella enteritidis R-6 ecp-schomo strain has been deposited in the All-Russian Collection of Microorganisms under the number BKMB-3828D.
Earlier, the Gamaleya Center submitted documents to the Ministry of Health for registration of an mRNA cancer vaccine. Russian scientists have also identified a link between COVID-19 and bone tissue destruction.